Rapid synthesis of oligoribonucleotides using 2′- O-( o-nitrobenzyloxymethyl)-protected monomers

A new, easily introduced protecting group for ribonucleoside 2′-hydroxyls, o-nitrobenzyloxymethyl, permits fast, effective solid phase synthesis of RNA. A new, easily introduced protecting group for ribonucleoside 2′ hydroxyls, o-nitrobenzyloxymethyl, permits fast, effective solid phase synthesis of...

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 2; no. 9; pp. 1019 - 1024
Main Authors Schwartz, M.E., Breaker, R.R., Asteriadis, G.T., deBear, J.S., Gough, G.R.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.09.1992
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Summary:A new, easily introduced protecting group for ribonucleoside 2′-hydroxyls, o-nitrobenzyloxymethyl, permits fast, effective solid phase synthesis of RNA. A new, easily introduced protecting group for ribonucleoside 2′ hydroxyls, o-nitrobenzyloxymethyl, permits fast, effective solid phase synthesis of RNA.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(00)80610-1