The radial immunodiffusion assay for plasma Histidine-rich Glycoprotein (HRG) based on a polyclonal antibody, shows a different specificity towards the two variants of a common amino acid polymorphism

Recently, two molecular weight forms of Histidine-rich Glycoprotein have been described which explain 59% of the variation in plasma HRG levels. Here, we demonstrate that this can partly be ascribed to a difference in specificity of the immuno assay for HRG towards the two alleles of the polymorphis...

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Bibliographic Details
Published inFibrinolysis Vol. 10; pp. 133 - 134
Main Authors Hennis, B.C., Hoffmann, J.J.M.L., Kluft, C.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.06.1996
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Summary:Recently, two molecular weight forms of Histidine-rich Glycoprotein have been described which explain 59% of the variation in plasma HRG levels. Here, we demonstrate that this can partly be ascribed to a difference in specificity of the immuno assay for HRG towards the two alleles of the polymorphism.
ISSN:0268-9499
DOI:10.1016/S0268-9499(96)80068-3