Effect of pristine fullerene on acquisition, consolidation and retrieval memory in wistar rats

• Published in: Comparative biochemistry and physiology. Toxicology & pharmacology Vol. 232; p. 108740
• Main Authors: Santa-Helena, Eduarda, Seus, Natália, Castro, Micheli
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2020
• Subjects: Animals; Avoidance Learning - drug effects; Brain - drug effects; Brain - physiopathology; Fullerenes - toxicity; inhibitory avoidance; Lipid Peroxidation; Memory; Mental Recall - drug effects; Nanomaterials; Nanotoxicology; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species - metabolism; Oxidative stress; Nanomaterials; inhibitory avoidance; Nanotoxicology; Memory
• ISSN: 1532-0456; 1878-1659
• DOI: 10.1016/j.cbpc.2020.108740

The present study evaluated the effect of fullerene (C60) under in vitro conditions, in hippocampus homogenates from rats and on the induction of behavioral disabilities. Exposure to in vitro C60 led to an increase in the concentration of reactive oxygen species (ROS) and lipid peroxidation (LPO) of hippocampus treated with of fullerene and suspension. These results indicate that the oxidative stress caused by the exposure to C60 was in part related to an absence of an antioxidant response. In this sense, one-trial inhibitory avoidance task were performed and results showed that fullerene at 0.2 and 0.45 μm impaired the acquisition and consolidation of short and long-term memory. Further, enzymatic analysis in rat hippocampus were not significantly different, however, there was an increase in the content of LPO and ROS produced by fullerene. Overall, the results indicates that fullerene possess neurotoxic properties that impairs behavior and promotes oxidative stress. [Display omitted] •The intrahippocampal infusion of fullerene suspension change learning.•Fullerene exposure increases reactive oxygen species and causes lipid damage.•Fullerene has neurotoxic effects.