On the International Agency for Research on Cancer classification of glyphosate as a probable human carcinogen

• Published in: European journal of cancer prevention Vol. 27; no. 1; p. 82
• Main Author: Tarone, Robert E
• Format: Journal Article
• Language: English
• Published: England 01.01.2018
• Subjects: Animals; Carcinogenicity Tests; Carcinogens - toxicity; Glycine - analogs & derivatives; Glycine - toxicity; Glyphosate; Humans; International Agencies - legislation & jurisprudence; International Agencies - standards; Models, Animal; Neoplasms - etiology; Neoplasms - prevention & control
• ISSN: 1473-5709
• DOI: 10.1097/CEJ.0000000000000289

The recent classification by International Agency for Research on Cancer (IARC) of the herbicide glyphosate as a probable human carcinogen has generated considerable discussion. The classification is at variance with evaluations of the carcinogenic potential of glyphosate by several national and international regulatory bodies. The basis for the IARC classification is examined under the assumptions that the IARC criteria are reasonable and that the body of scientific studies determined by IARC staff to be relevant to the evaluation of glyphosate by the Monograph Working Group is sufficiently complete. It is shown that the classification of glyphosate as a probable human carcinogen was the result of a flawed and incomplete summary of the experimental evidence evaluated by the Working Group. Rational and effective cancer prevention activities depend on scientifically sound and unbiased assessments of the carcinogenic potential of suspected agents. Implications of the erroneous classification of glyphosate with respect to the IARC Monograph Working Group deliberative process are discussed.