Harnessing balloon flower root-derived nanovesicles to mitigate hyperglycemia-induced cellular senescence

Diabetes mellitus, a global health concern, is characterized by chronic hyperglycemia, which leads to severe complications and imposes substantial economic and healthcare burdens. Elevated blood glucose levels induce cellular senescence, impairing wound healing and contributing to chronic wounds in...

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Published inBiotechnology and bioprocess engineering Vol. 30; no. 3; pp. 534 - 546
Main Authors Kim, Manho, Kim, Doyeon, Jang, Hyejun, Park, Ju Hyun
Format Journal Article
LanguageEnglish
Published Seoul The Korean Society for Biotechnology and Bioengineering 01.06.2025
Springer Nature B.V
한국생물공학회
Subjects
Antioxidants
Balloon treatment
Balloons
Biotechnology
Blood levels
Cell migration
Chemistry
Chemistry and Materials Science
Cold storage
Diabetes
Diabetes mellitus
Flowers
Gene expression
Global health
Glucose
Hyperglycemia
Industrial and Production Engineering
Patients
Polyethylene glycol
Public health
Research Paper
Senescence
Size distribution
Ultracentrifugation
Wound healing
생물공학
Balloon flower root
Anti-senescence
Hyperglycemia
Antioxidant
Plant-derived nanovesicle
Diabetic wound healing
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Summary:Diabetes mellitus, a global health concern, is characterized by chronic hyperglycemia, which leads to severe complications and imposes substantial economic and healthcare burdens. Elevated blood glucose levels induce cellular senescence, impairing wound healing and contributing to chronic wounds in diabetic patients. This study investigates the potential of balloon flower root ( Platycodon grandiflorus )-derived nanovesicles (BFR-NVs), known for their potent antioxidant properties, to mitigate hyperglycemia-induced impairments in wound healing. BFR-NVs were isolated using a hybrid method combining polyethylene glycol-based precipitation and ultracentrifugation, yielding vesicles with stable size distribution over two weeks of refrigerated storage. In vitro, treatment of high-glucose-induced senescent human dermal fibroblasts with BFR-NVs resulted in reduced expression of senescence-associated markers, normalization of gene expression profiles, and enhanced cellular proliferation and migration. These findings indicate the potential therapeutic role of BFR-NVs in mitigating hyperglycemia-induced senescence-associated cellular dysfunction. The antioxidant properties of BFR-NVs may play a crucial role in restoring cellular function, providing valuable insights for future research and clinical applications aimed at improving wound healing in diabetic patients. Graphical abstract
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ISSN:1226-8372
1976-3816
DOI:10.1007/s12257-025-00195-w