A methylene bridge as protecting group. 1. Selective preparation of 4-alkyl-1,2,4-triazoles

An efficient preparation of the title compounds is described. Easily accessible bis(1,2,4-triazol-1-yl)methane is transformed into double azolium salts which, by nucleophilic substitution, yield 4-substituted-1,2,4-triazoles. The method involves the use of a methylene moiety as a protecting group fo...

Full description

Saved in:
Bibliographic Details
Published inTetrahedron Vol. 53; no. 6; pp. 2253 - 2260
Main Authors Diez-Barra, Enrique, de la Hoz, Antonio, Rodríguez-Curiel, RenéI., Tejeda, Juan
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 10.02.1997
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
N-ALKYLATION
DERIVATIVES
INHIBITORS
Online AccessGet full text

Cover

More Information
Summary:An efficient preparation of the title compounds is described. Easily accessible bis(1,2,4-triazol-1-yl)methane is transformed into double azolium salts which, by nucleophilic substitution, yield 4-substituted-1,2,4-triazoles. The method involves the use of a methylene moiety as a protecting group for the two azole units. The methodology described opens new possibilities for the preparation of the least common regiosomer in N-substituted heterocycles
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(96)01127-1