Local Recurrence Rates of Extramammary Paget Disease Are Lower After Mohs Micrographic Surgery Compared With Wide Local Excision: A Systematic Review and Meta-Analysis

• Published in: Dermatologic surgery Vol. 49; no. 1; p. 8
• Main Authors: Kim, Grace Y, Campbell, Elliott H, Brewer, Jerry D
• Format: Journal Article
• Language: English
• Published: United States 01.01.2023
• Subjects: Aged; Humans; Mohs Surgery; Neoplasm Recurrence, Local - surgery; Paget Disease, Extramammary - pathology; Paget Disease, Extramammary - surgery; Retrospective Studies; Skin Neoplasms - pathology; Skin Neoplasms - surgery
• ISSN: 1524-4725
• DOI: 10.1097/DSS.0000000000003601

Extramammary Paget disease (EMPD) is a rare, slow growing neoplasm that presents most commonly in the anogenital region of older adults. To analyze the difference in local recurrence rates of EMPD in patients treated with wide local excision (WLE) versus Mohs micrographic surgery (MMS). A systematic review of the literature and meta-analysis were performed. Inclusion criteria were adults greater than 18 years of age with a diagnosis of EMPD who have undergone surgical intervention and had follow-up data. Studies were independently reviewed by 2 coinvestigators with discrepancies resolved by the principal investigator. Twenty-seven studies met the inclusion criteria. Patients had a 2.67 times higher chance of local recurrence after WLE than MMS (95% confidence interval [CI]:1.47, 4.85; p = .001). Meta-analysis of single-arm studies revealed a 7.3% local recurrence rate after MMS (95% CI: 0.039, 0.107; p < .001) versus a 26.3% recurrence rate after WLE (95% CI: 0.149, 0.376; p < .001). After excluding recurrent tumors, the odds ratio for recurrence in WLE versus MMS was 2.3 (95% CI: 0.285, 18.43, p = .435). There is a clinically and statistically increased risk of local recurrence of EMPD after WLE compared with MMS.