A novel esterification procedure applied to synthesis of biologically active esters of Foscarnet

• Published in: Tetrahedron letters Vol. 38; no. 16; pp. 2791 - 2794
• Main Authors: Gorin, Boris I., Ferguson, Colin G., Thatcher, Gregory R.J.
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 21.04.1997; Elsevier
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; ACCELERATION; PHOSPHORUS; PRODUCTS; PRODRUGS; KINETICS; NUCLEOPHILIC-SUBSTITUTION; HYDROLYSIS; PHOSPHONOFORMATE

The high reactivity of the phosphonoformate moiety requires development of a novel synthesis for esters of phosphonoformate, which is reported together with preliminary data on the antiviral activity of these esters. The development of a novel synthesis for esters of phosphonoformate is reported tog...