A novel esterification procedure applied to synthesis of biologically active esters of Foscarnet

The high reactivity of the phosphonoformate moiety requires development of a novel synthesis for esters of phosphonoformate, which is reported together with preliminary data on the antiviral activity of these esters. The development of a novel synthesis for esters of phosphonoformate is reported tog...

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Bibliographic Details
Published inTetrahedron letters Vol. 38; no. 16; pp. 2791 - 2794
Main Authors Gorin, Boris I., Ferguson, Colin G., Thatcher, Gregory R.J.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 21.04.1997
Elsevier
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Summary:The high reactivity of the phosphonoformate moiety requires development of a novel synthesis for esters of phosphonoformate, which is reported together with preliminary data on the antiviral activity of these esters. The development of a novel synthesis for esters of phosphonoformate is reported together with preliminary data on the antiviral activity for these esters.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(97)00491-7