A novel esterification procedure applied to synthesis of biologically active esters of Foscarnet

The high reactivity of the phosphonoformate moiety requires development of a novel synthesis for esters of phosphonoformate, which is reported together with preliminary data on the antiviral activity of these esters. The development of a novel synthesis for esters of phosphonoformate is reported tog...

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Published inTetrahedron letters Vol. 38; no. 16; pp. 2791 - 2794
Main Authors Gorin, Boris I., Ferguson, Colin G., Thatcher, Gregory R.J.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 21.04.1997
Elsevier
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Abstract The high reactivity of the phosphonoformate moiety requires development of a novel synthesis for esters of phosphonoformate, which is reported together with preliminary data on the antiviral activity of these esters. The development of a novel synthesis for esters of phosphonoformate is reported together with preliminary data on the antiviral activity for these esters.
AbstractList The high reactivity of the phosphonoformate moiety requires development of a novel synthesis for esters of phosphonoformate, which is reported together with preliminary data on the antiviral activity of these esters. The development of a novel synthesis for esters of phosphonoformate is reported together with preliminary data on the antiviral activity for these esters.
The high reactivity of the phosphonoformate moiety requires development of a novel synthesis for esters of phosphonoformate, which is reported together with preliminary data on the antiviral activity of these esters. (C) 1997 Elsevier Science Ltd.
Author Thatcher, Gregory R.J.
Ferguson, Colin G.
Gorin, Boris I.
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Cites_doi 10.1039/p29920001145
10.1016/0163-7258(89)90097-1
10.1021/jm00158a012
10.1039/p29930000793
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10.1039/c39910000118
10.1039/p29910001297
10.1021/jm00356a028
10.1016/S0378-4347(00)82968-0
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Issue 16
Keywords ACCELERATION
PHOSPHORUS
PRODUCTS
PRODRUGS
KINETICS
NUCLEOPHILIC-SUBSTITUTION
HYDROLYSIS
PHOSPHONOFORMATE
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Snippet The high reactivity of the phosphonoformate moiety requires development of a novel synthesis for esters of phosphonoformate, which is reported together with...
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SubjectTerms Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
Title A novel esterification procedure applied to synthesis of biologically active esters of Foscarnet
URI https://dx.doi.org/10.1016/S0040-4039(97)00491-7
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