A novel esterification procedure applied to synthesis of biologically active esters of Foscarnet
The high reactivity of the phosphonoformate moiety requires development of a novel synthesis for esters of phosphonoformate, which is reported together with preliminary data on the antiviral activity of these esters. The development of a novel synthesis for esters of phosphonoformate is reported tog...
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Published in | Tetrahedron letters Vol. 38; no. 16; pp. 2791 - 2794 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
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Elsevier Ltd
21.04.1997
Elsevier |
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Abstract | The high reactivity of the phosphonoformate moiety requires development of a novel synthesis for esters of phosphonoformate, which is reported together with preliminary data on the antiviral activity of these esters.
The development of a novel synthesis for esters of phosphonoformate is reported together with preliminary data on the antiviral activity for these esters. |
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AbstractList | The high reactivity of the phosphonoformate moiety requires development of a novel synthesis for esters of phosphonoformate, which is reported together with preliminary data on the antiviral activity of these esters.
The development of a novel synthesis for esters of phosphonoformate is reported together with preliminary data on the antiviral activity for these esters. The high reactivity of the phosphonoformate moiety requires development of a novel synthesis for esters of phosphonoformate, which is reported together with preliminary data on the antiviral activity of these esters. (C) 1997 Elsevier Science Ltd. |
Author | Thatcher, Gregory R.J. Ferguson, Colin G. Gorin, Boris I. |
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Cites_doi | 10.1039/p29920001145 10.1016/0163-7258(89)90097-1 10.1021/jm00158a012 10.1039/p29930000793 10.1039/p29940000683 10.1016/S0040-4039(01)93918-8 10.1039/c39910000118 10.1039/p29910001297 10.1021/jm00356a028 10.1016/S0378-4347(00)82968-0 |
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Keywords | ACCELERATION PHOSPHORUS PRODUCTS PRODRUGS KINETICS NUCLEOPHILIC-SUBSTITUTION HYDROLYSIS PHOSPHONOFORMATE |
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Perkin Trans. 2 contributor: fullname: Freeman – start-page: 1297 year: 1991 ident: WOS:A1991GB33100035 article-title: PRODRUGS OF PHOSPHONOFORMATE - PRODUCTS, KINETICS AND MECHANISMS OF HYDROLYSIS OF DIBENZYL (METHOXYCARBONYL)PHOSPHONATE publication-title: JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 contributor: fullname: MITCHELL, AG – start-page: 7141 year: 1989 ident: WOS:A1997WV21200003.1 publication-title: TETRAHEDRON LETT contributor: fullname: IYER RP – start-page: 1145 year: 1992 ident: WOS:A1992JD46800023 article-title: PRODRUGS OF PHOSPHONOFORMATE - THE EFFECT OF PARASUBSTITUENTS ON THE PRODUCTS, KINETICS AND MECHANISM OF HYDROLYSIS OF DIBENZYL METHOXYCARBONYLPHOSPHONATE publication-title: JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 contributor: fullname: MITCHELL, AG – start-page: 683 year: 1994 ident: WOS:A1994NF45100006 article-title: STEREOELECTRONIC EFFECTS IN PENTACOORDINATE INTERMEDIATES AND ACCELERATION OF NUCLEOPHILIC-SUBSTITUTION AT PHOSPHORUS publication-title: JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 contributor: fullname: THATCHER, GRJ – start-page: 618 year: 1971 ident: WOS:A1971J185000003 article-title: ACID-CATALYSED DECARBOXYLATION OF PHOSPHONOFORMIC ACID publication-title: JOURNAL OF THE CHEMICAL SOCIETY B-PHYSICAL ORGANIC contributor: fullname: WARREN, S – start-page: 118 year: 1991 ident: WOS:A1991EW60400037 article-title: HYDROLYSIS OF PHOSPHONOFORMATE ESTERS - PRODUCT DISTRIBUTION AND REACTIVITY PATTERNS publication-title: JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS contributor: fullname: KROL, ES – volume: 26 start-page: 264 year: 1983 ident: WOS:A1983PZ65200028 article-title: SYNTHESIS OF ESTERS OF PHOSPHONOFORMIC ACID AND THEIR ANTIHERPES ACTIVITY publication-title: JOURNAL OF MEDICINAL CHEMISTRY contributor: fullname: NOREN, JO – volume: 40 start-page: 213 year: 1989 ident: WOS:A1989R518600003 article-title: ANTIVIRAL EFFECTS OF PHOSPHONOFORMATE (PFA, FOSCARNET SODIUM) publication-title: PHARMACOLOGY & THERAPEUTICS contributor: fullname: OBERG, B – volume: 29 start-page: 1389 year: 1986 ident: WOS:A1986D452700012 article-title: SYNTHESIS AND ANTIVIRAL ACTIVITY OF CERTAIN NUCLEOSIDE 5'-PHOSPHONOFORMATE DERIVATIVES publication-title: JOURNAL OF MEDICINAL CHEMISTRY contributor: fullname: VAGHEFI, MM – volume: 20 start-page: 789 year: 1981 ident: WOS:A1981MM74800023 article-title: SYNTHESIS OF HIGHLY REACTIVE CYCLIC ENEDIOL PHOSPHATES AND CYCLIC ACYL PHOSPHATES BY DIRECT PHOSPHORYLATING RING-CLOSURE publication-title: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH contributor: fullname: SCHWARZ, R – start-page: 793 year: 1993 ident: WOS:A1993LB78100001 article-title: HYDROLYSIS OF PHOSPHONOFORMATE TRIESTERS - RATE ACCELERATION OF A MILLIONFOLD IN NUCLEOPHILIC-SUBSTITUTION AT PHOSPHORUS publication-title: JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 contributor: fullname: KROL, ES – volume: 488 start-page: 447 year: 1989 ident: WOS:A1989U171100014 article-title: DETERMINATION OF PHOSPHONOFORMATE (FOSCARNET) IN BIOLOGICAL-FLUIDS BY ION-PAIR REVERSED-PHASE LIQUID-CHROMATOGRAPHY publication-title: JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS contributor: fullname: PETTERSSON, KJ – start-page: 1145 year: 1992 ident: 10.1016/S0040-4039(97)00491-7_BIB3 publication-title: J. Chem. Soc. Perkin Trans. 2 doi: 10.1039/p29920001145 contributor: fullname: Mitchell – volume: 40 start-page: 213 year: 1989 ident: 10.1016/S0040-4039(97)00491-7_BIB1 publication-title: Pharmac. Ther. doi: 10.1016/0163-7258(89)90097-1 contributor: fullname: Oberg – volume: 29 start-page: 1389 year: 1986 ident: 10.1016/S0040-4039(97)00491-7_BIB10 publication-title: J. Med. Chem. doi: 10.1021/jm00158a012 contributor: fullname: Vaghefi – start-page: 793 year: 1993 ident: 10.1016/S0040-4039(97)00491-7_BIB8 publication-title: J. Chem. Soc. Perkin Trans. 2 doi: 10.1039/p29930000793 contributor: fullname: Krol – start-page: 683 year: 1994 ident: 10.1016/S0040-4039(97)00491-7_BIB6 publication-title: J. Chem. Soc. Perkin Trans. 2 doi: 10.1039/p29940000683 contributor: fullname: Thatcher – start-page: 7141 year: 1989 ident: 10.1016/S0040-4039(97)00491-7_BIB9 publication-title: Tetrahedron Lett. doi: 10.1016/S0040-4039(01)93918-8 contributor: fullname: Iyer – start-page: 118 year: 1991 ident: 10.1016/S0040-4039(97)00491-7_BIB7 publication-title: J. Chem. Soc. Chem. Commun. doi: 10.1039/c39910000118 contributor: fullname: Krol – start-page: 618 year: 1971 ident: 10.1016/S0040-4039(97)00491-7_BIB5 publication-title: J. Chem. Soc. (B) contributor: fullname: Warren – start-page: 1297 year: 1991 ident: 10.1016/S0040-4039(97)00491-7_BIB2 publication-title: J. Chem. Soc. Perkin Trans. 2 doi: 10.1039/p29910001297 contributor: fullname: Mitchell – volume: 26 start-page: 264 year: 1983 ident: 10.1016/S0040-4039(97)00491-7_BIB4 publication-title: J. Med. Chem. doi: 10.1021/jm00356a028 contributor: fullname: Noren – volume: 488 start-page: 447 year: 1989 ident: 10.1016/S0040-4039(97)00491-7_BIB11 publication-title: J. Chromat. doi: 10.1016/S0378-4347(00)82968-0 contributor: fullname: Petterson |
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Title | A novel esterification procedure applied to synthesis of biologically active esters of Foscarnet |
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