Split-split. A multiple synthesiser approach to efficient automated parallel synthesis

A multiple synthesiser approach to high efficiency, high throughput synthesis is described. It involves eliminating duplication in multi-step synthesis by establishing a cascade of matched synthesisers in which each machine performs a single step and provides feedstocks for the next instrument. The...

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Bibliographic Details
Published inTetrahedron letters Vol. 40; no. 7; pp. 1405 - 1408
Main Authors Brooking, Paul, Doran, Andrew, Grimsey, Paul, Hird, Nicholas W., MacLachlan, William S., Vimal, Mythily
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 12.02.1999
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
COMBINATORIAL CHEMISTRY
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Summary:A multiple synthesiser approach to high efficiency, high throughput synthesis is described. It involves eliminating duplication in multi-step synthesis by establishing a cascade of matched synthesisers in which each machine performs a single step and provides feedstocks for the next instrument. The utility of this approach is illustrated by the efficient construction of a large array by a 4 step solution synthesis. A multiple synthesiser approach to high-efficiency, high-throughput solution phase synthesis is described
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(98)02620-3