Rapid synthesis of substituted 5-phenyl-1,3-dioxolan-4-ones under microwave-induced solvent-free conditions

Under microwave irradiation and without solvent, racemic and optically pure mandelic acid readily condenses with aldehydes and ketones to give 2-alkyl substituted 5-phenyl-1,3-dioxolan-4-ones in good yield. Graphic

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Bibliographic Details
Published inTetrahedron letters Vol. 44; no. 12; pp. 2573 - 2576
Main Authors Ferrett, Rochelle R., Hyde, Michael J., Lahti, Kimberly A., Friebe, Timothy L.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 17.03.2003
Elsevier
Subjects
Chemistry
Chemistry, Organic
condensation
dioxolane
microwave-induced
Physical Sciences
Science & Technology
solvent-free conditions
condensation
dioxolane
microwave-induced
solvent-free conditions
ALCOHOLS
ORGANIC-SYNTHESIS
1,3-DIOXOLAN-4-ONES
MANDELIC-ACID
CARBOXYLIC-ACIDS
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Summary:Under microwave irradiation and without solvent, racemic and optically pure mandelic acid readily condenses with aldehydes and ketones to give 2-alkyl substituted 5-phenyl-1,3-dioxolan-4-ones in good yield. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(03)00280-6