Lemierre's Syndrome as a Trigger for Secondary Hemophagocytic Lymphohistiocytosis

Secondary hemophagocytic lymphohistiocytosis (sHLH) is a rare hyperinflammatory disorder caused by an aberrant immune response to a number of infectious or inflammatory conditions. Successful treatment of this potentially fatal condition requires early recognition and prompt therapy directed at the...

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Bibliographic Details
Published inJournal of pediatric hematology/oncology Vol. 39; no. 6; p. e325
Main Authors Kumral, Abigail V W, Petersen, Jr, William C, Heitz, Christopher, Waggoner-Fountain, Linda A, Belyea, Brian C
Format Journal Article
LanguageEnglish
Published United States 01.08.2017
Subjects
Adolescent
Diagnosis, Differential
Disease Management
Female
Humans
Lemierre Syndrome - complications
Lymphohistiocytosis, Hemophagocytic - diagnosis
Lymphohistiocytosis, Hemophagocytic - etiology
Lymphohistiocytosis, Hemophagocytic - therapy
Treatment Outcome
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Summary:Secondary hemophagocytic lymphohistiocytosis (sHLH) is a rare hyperinflammatory disorder caused by an aberrant immune response to a number of infectious or inflammatory conditions. Successful treatment of this potentially fatal condition requires early recognition and prompt therapy directed at the underlying trigger. In this report, we describe the clinical presentation, diagnostic findings, management, and outcome of a child with Lemierre's syndrome-associated sHLH. This is the first reported association of these 2 rare conditions and expands the number of known triggers for sHLH.
ISSN:1536-3678
DOI:10.1097/MPH.0000000000000755