Synthesis of optically pure ( S)-2-acetylthio-3-benzenepropanoic acid via enzymatic resolution

A method of synthesizing optically pure ( S)-2-acetylthio-3-benzenepropanoic acid has been developed and good to excellent enantiomeric excess achieved via enzymatic resolution. Optically pure 2-acetylthio-3-benzenepropanoic acid can be obtained in good yield via enzymatic resolution.

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Bibliographic Details
Published inTetrahedron letters Vol. 43; no. 42; pp. 7585 - 7587
Main Authors Zhu, Jingyang, You, Li, Zhao, Shannon X, White, Brenda, Chen, Jason G, Skonezny, Paul M
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 14.10.2002
Elsevier
Subjects
2-acetylthio-3-benzenepropanoic acid
Chemistry
Chemistry, Organic
enzymatic resolution
enzyme
Physical Sciences
Science & Technology
enzyme
enzymatic resolution
2-acetylthio-3-benzenepropanoic acid
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Summary:A method of synthesizing optically pure ( S)-2-acetylthio-3-benzenepropanoic acid has been developed and good to excellent enantiomeric excess achieved via enzymatic resolution. Optically pure 2-acetylthio-3-benzenepropanoic acid can be obtained in good yield via enzymatic resolution.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(02)01820-8