Molecular mobility of amorphous pharmaceuticals determined using differential scanning calorimetry

Amorphous pharmaceutical materials have received considerable attention in recent years because of their unique handling, processing and stability characteristics. A key question that arises with such materials is “what is the molecular mobility of the material, and how does this influence its perfo...

Full description

Saved in:
Bibliographic Details
Published inThermochimica acta Vol. 380; no. 2; pp. 95 - 107
Main Authors Hancock, Bruno C, Shamblin, Sheri L
Format Journal Article
LanguageEnglish
Published Elsevier B.V 14.12.2001
Subjects
Amorphous
Differential scanning calorimetry
Fragility
Glass transition temperature
Molecular mobility
Relaxation time
Stability
Amorphous
Differential scanning calorimetry
Stability
Molecular mobility
Glass transition temperature
Relaxation time
Fragility
Online AccessGet full text

Cover

More Information
Summary:Amorphous pharmaceutical materials have received considerable attention in recent years because of their unique handling, processing and stability characteristics. A key question that arises with such materials is “what is the molecular mobility of the material, and how does this influence its performance?”. In this manuscript, the use of differential scanning calorimetry (DSC) to characterize the molecular mobility of amorphous pharmaceutical materials is reviewed, and several applications of the data for the qualitative and quantitative prediction of their performance are presented.
ISSN:0040-6031
1872-762X
DOI:10.1016/S0040-6031(01)00663-3