Positron emission tomography (PET) advances in neurological applications

Positron Emission Tomography (PET) is a functional imaging modality used in brain research to map in vivo neurotransmitter and receptor activity and to investigate glucose utilization or blood flow patterns both in healthy and disease states. Such research is made possible by the wealth of radiotrac...

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Bibliographic Details
Published inNuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment Vol. 510; no. 1; pp. 107 - 115
Main Author Sossi, V
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.09.2003
Subjects
Detectors
Kinetic modeling
Positron emission tomography brain imaging
Quantification
28.41.Rc
87.59.e
Quantification
Kinetic modeling
Detectors
87.59.Vb
Positron emission tomography brain imaging
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Summary:Positron Emission Tomography (PET) is a functional imaging modality used in brain research to map in vivo neurotransmitter and receptor activity and to investigate glucose utilization or blood flow patterns both in healthy and disease states. Such research is made possible by the wealth of radiotracers available for PET, by the fact that metabolic and kinetic parameters of particular processes can be extracted from PET data and by the continuous development of imaging techniques. In recent years great advancements have been made in the areas of PET instrumentation, data quantification and image reconstruction that allow for more detailed and accurate biological information to be extracted from PET data. It is now possible to quantitatively compare data obtained either with different tracers or with the same tracer under different scanning conditions. These sophisticated imaging approaches enable detailed investigation of disease mechanisms and system response to disease and/or therapy.
ISSN:0168-9002
1872-9576
DOI:10.1016/S0168-9002(03)01686-3