Silver-Catalyzed 2-Pyridyl Arylation of Pyridine N-Oxides with Arylboronic Acids at Room Temperature

A novel direct arylation of pyridine N-oxides with arylboronic acids through C-H functionalization has been developed. This new reaction is performed at room temperature using catalytic silver(I) nitrate in the presence of potassium persulfate and give 2-pyridyl arylation derivatives of pyridine N-o...

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Bibliographic Details
Published inSynlett Vol. 23; no. 1; pp. 145 - 149
Main Authors Mai, Wenpeng, Yuan, Jinwei, Li, Zhicheng, Sun, Gangchun, Qu, Lingbo
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 01.01.2012
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
PALLADIUM
pyridine N-oxides
BOND FORMATION
SODIUM PERSULFATE
UNACTIVATED ARENES
ANILIDES
CLEAVAGE
C-H ACTIVATION
arylation
FUNCTIONALIZATION
OLEFINATION
silver
ALKENYLATION
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Summary:A novel direct arylation of pyridine N-oxides with arylboronic acids through C-H functionalization has been developed. This new reaction is performed at room temperature using catalytic silver(I) nitrate in the presence of potassium persulfate and give 2-pyridyl arylation derivatives of pyridine N-oxides.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0031-1290088