Preparation of the 14-membered l, l-cycloisodityrosine subunit of RP 66453

The synthesis of the reversed 14-membered l, l-cycloisodityrosine 9 constituting an appropriately functionalized BC ring system of RP 66453 is detailed. Graphic

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Bibliographic Details
Published inTetrahedron letters Vol. 43; no. 3; pp. 407 - 410
Main Authors Krenitsky, Paul J., Boger, Dale L.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 14.01.2002
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
CYCLOISODITYROSINE SUBUNIT
(9S,12S)-CYCLOISODITYROSINE
ANTITUMOR CYCLIC HEXAPEPTIDES
VANCOMYCIN
BOUVARDIN
PIPERAZINOMYCIN
DEOXYBOUVARDIN
DIARYL ETHERS
MACROCYCLIZATION
RA-VII
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Summary:The synthesis of the reversed 14-membered l, l-cycloisodityrosine 9 constituting an appropriately functionalized BC ring system of RP 66453 is detailed. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(01)02194-3