Ligustolide A and B, two novel sesquiterpenes with rare skeletons and three 1,10- seco-guaianolide derivatives from Achillea ligustica

• Published in: Tetrahedron Vol. 59; no. 21; pp. 3729 - 3735
• Main Authors: Ahmed, Ahmed A, Gáti, Tamás, Hussein, Taha A, Ali, Aptehal T, Tzakou, Olga A, Couladis, Maria A, Mabry, Tom J, Tóth, Gábor
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 19.05.2003; Elsevier
• Subjects: Achillea ligustica; Chemistry; Chemistry, Organic; ligustolide A and B; Physical Sciences; Science & Technology; sesquiterpenes; ligustolide A and B; Achillea ligustica; sesquiterpenes; LACTONES; ARTEMISIA; GUAIANOLIDES; CONSTITUENTS; HOLOSERICEA
• ISSN: 0040-4020; 1464-5416
• DOI: 10.1016/S0040-4020(03)00572-6

Achillea ligustica afforded two novel sesquiterpene lactones with rare 5/6/5 skeletons, three 1,10- seco-guaianolides and a chlorine-containing sesquiterpene lactone as well as six known compounds, including two monoterpenes, two guaianolides, one eudesmane and one secocaryophyllene derivative. The structures of the compounds were elucidated by extensive application of one- and two-dimensional NMR spectroscopy. Fractionation of the extract of Achillea ligustica afforded two novel sesquiterpene lactones with rare 5/6/5 skeletons, three 1,10- seco-guaianolides and a chlorine-containing sesquiterpene lactone as well as six known compounds, including two monoterpenes, two guaianolides, one eudesmane and one secocaryophyllene derivative. The structures of the compounds were elucidated by extensive application of one- and two-dimensional NMR spectroscopy.