Stereocontrol in one-pot syntheses of 1,3-diols

Titanium mediated aldol addition reduction sequence is described for the synthesis of stereodefined 1,3-diols. Diastereochemical control is surprisingly achieved through the careful selection of starting materials used. Graphic

Saved in:
Bibliographic Details
Published inTetrahedron Vol. 55; no. 49; pp. 14005 - 14012
Main Authors Mahrwald, R., Ziemer, B.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 03.12.1999
Elsevier
Subjects
aldol reaction
Chemistry
Chemistry, Organic
diols
Physical Sciences
reduction
Science & Technology
stereocontrol
aldol reaction
diols
reduction
stereocontrol
REAGENTS
ACID
ALDEHYDES
TITANIUM
CENTERS
STEREOSELECTIVE SYNTHESIS
REDUCTIONS
KETONES
POLYPROPIONATE SYNTHESIS
ALDOL ADDITION
Online AccessGet full text

Cover

More Information
Summary:Titanium mediated aldol addition reduction sequence is described for the synthesis of stereodefined 1,3-diols. Diastereochemical control is surprisingly achieved through the careful selection of starting materials used. Graphic
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(99)00868-6