Emerging neuroprotective potential of Liquorice: Mechanistic insights for neurological disorders

• Published in: South African journal of botany Vol. 154; pp. 149 - 158
• Main Authors: Sarkar, Sampriti, Shaw, Payel, Singh, Paramjeet, Acharya Chowdhury, Avik
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.03.2023
• Subjects: Alzheimer disease; antioxidants; botany; cytotoxicity; Glycyrrhiza glabra; licorice; Liquorice; medicinal plants; Molecular mechanism; Natural product; Neuroprotection; neuroprotective effect; Parkinson disease; stroke; therapeutics; Neuroprotection; Molecular mechanism; JNK; rtPA; ALS; HMGB1; MDA; MPP; AP-1; TNF; NF-κB; iNOS; GA; AIF; Liquorice; AD; IL; ISL; GL; MS; Natural product; IS; PD; Glycyrrhiza glabra; ROS; MPTP; HD; ERK
• ISSN: 0254-6299; 1727-9321
• DOI: 10.1016/j.sajb.2023.01.029

•Documentation of neuroprotective potential of licorice as a medicinal plant.•In vivo and in vitro neuroprotection of active constituents isolated from liquorice discussed.•Mode of action of liquorice and its active constituents have been summarized. Conventional natural remedies have been standing out as forthcoming alternatives of treatment for different diseases across several countries. In recent years, restorative plants have been acquiring more acceptance because these plants, as natural items, make less side effects and further develop adequacy in comparison to the chemically synthesized products.  Liquorice is such a medicinal plant with unique therapeutic values and applications in conventional pharmacology. Several researches have confirmed its clinical adequacy in various medical conditions, which includes the neuroprotective role of Liquorice and its dynamic components in chronic or acute neurodegenerative cycles, along with its antioxidant, antifungal, anticarcinogenic, anti-inflammatory, and cytotoxic activities. Preclinical discoveries uphold the fact that Liquorice might be a promising remedial choice against neurological problems, with the potential of inhibiting the progression of disease. In the current review, we have discussed the neuroprotective impacts of Liquorice and its components in persistent neurologic problems such as Ischemic stroke, Alzheimer's, Huntington's diseases, and Parkinson's disease both in cellular and molecular level. The study also aims to shed light upon the probable futuristic approaches towards the application and usage of Liquorice.