Ferrihemoglobin and kidney lesions in rats produced by 4-aminophenol or 4-dimethylaminophenol

4-Dimethylaminophenol hydrochloride (DMAP), 20mg/kg i.v., was found to oxidize in rats as much as 50% of the hemoglobin to ferrihemoglobin but did not cause kidney lesions. 4-Aminophenol hydrochloride, 400 mg/kg i.v., oxidized only 25% of the hemoglobin and produced large tubular necroses. In highly...

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Bibliographic Details
Published inArchives of toxicology Vol. 34; no. 4; p. 337
Main Authors Kiese, M, Szinicz, L, Thiel, N, Weger, N
Format Journal Article
LanguageEnglish
Published Germany 18.12.1975
Subjects
Animals
Antidotes
Cyanides - poisoning
Dose-Response Relationship, Drug
Glycosuria - chemically induced
Kidney Diseases - chemically induced
Lethal Dose 50
Male
Methemoglobin - biosynthesis
Phenols - toxicity
Rats
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Summary:4-Dimethylaminophenol hydrochloride (DMAP), 20mg/kg i.v., was found to oxidize in rats as much as 50% of the hemoglobin to ferrihemoglobin but did not cause kidney lesions. 4-Aminophenol hydrochloride, 400 mg/kg i.v., oxidized only 25% of the hemoglobin and produced large tubular necroses. In highly toxic doses only, e.g., twice the LD50, DMAP also produced tubular necroses.
ISSN:0340-5761
DOI:10.1007/BF00353854