Synthesis of 1-benzoyl-3-alkylthioureas by transamidation under microwave in dry media

1-Benzoyl-3,3-diethylthiourea was transamidated with several amines to the corresponding 1-benzoyl-3-alkylthioureas in open vessels under microwave irradiation using a domestic oven. The syntheses were performed in solvent-free conditions on potassium fluoride impregnated alumina. Yields were dramat...

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Bibliographic Details
Published inTetrahedron letters Vol. 41; no. 11; pp. 1753 - 1756
Main Authors Márquez, Heiddy, Pérez, Eduardo R, Plutı́n, Ana M, Morales, Margarita, Loupy, André
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 11.03.2000
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ORGANIC-SYNTHESIS
THIOUREAS
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Summary:1-Benzoyl-3,3-diethylthiourea was transamidated with several amines to the corresponding 1-benzoyl-3-alkylthioureas in open vessels under microwave irradiation using a domestic oven. The syntheses were performed in solvent-free conditions on potassium fluoride impregnated alumina. Yields were dramatically improved in comparison with classical heating under the same conditions.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(00)00047-2