Impact of neoadjuvant chemotherapy on short-term outcomes after simple and complex minimally invasive minor hepatectomy for colorectal liver metastases: A propensity-score matched and coarsened exact matched study

• Published in: European journal of surgical oncology Vol. 50; no. 6; p. 108309
• Main Authors: Hoogteijling, Tijs J., Abu Hilal, Mohammad, Zimmitti, Giuseppe, Aghayan, Davit L., Wu, Andrew G.R., Cipriani, Federica, Gruttadauria, Salvatore, Scatton, Olivier, Long, Tran Cong duy, Mazzaferro, Vincenzo, Chiow, Adrian K.H., Sucandy, Iswanto, Ivanecz, Arpad, Choi, Sung Hoon, Lee, Jae Hoon, Vivarelli, Marco, Giuliante, Felice, Ruzzenente, Andrea, Yong, Chee Chien, Yin, Mengqiu, Efanov, Mikhail, Morise, Zenichi, Di Benedetto, Fabrizio, Brustia, Raffaele, Dalla Valle, Raffaele, Boggi, Ugo, Geller, David, Belli, Andrea, Memeo, Riccardo, Mejia, Alejandro, Park, James O., Robles-Campos, Ricardo, Wang, Xiaoying, Sutcliffe, Robert P., Tang, Chung-Ngai, Chong, Charing C.N., D'Hondt, Mathieu, Lopez-Ben, Santiago, Kingham, T. Peter, Ferrero, Alessandro, Ettorre, Giuseppe Maria, Cherqui, Daniel, Liang, Xiao, Soubrane, Olivier, Troisi, Roberto I., Sugioka, Atsushi, Dokmak, Safi, Chen, Kuo Hsin, Liu, Rong, Aldrighetti, Luca, Goh, Brian K.P., Syn, Nicholas L., Prieto, Mikel, Meurs, Juul, De Meyere, Celine, Ng, Kelvin K., Salimgereeva, Diana, Thiruchelvam, Nita, Jang, Jae Young, Kato, Yutaro, Coelho, Fabricio Ferreira, Pirola Kruger, Jaime Arthur, Lopez-Lopez, Victor, Casellas I Robert, Margarida, Montalti, Roberto, Giglio, Mariano, Lee, Boram, D'Silva, Mizelle, Wang, Hao-Ping, Saleh, Mansour, Chen, Zewei, Yu, Shian, Ardito, Francesco, Mocchegiani, Federico, Colasanti, Marco, Berardi, Giammauro, Guzmán, Yoelimar, Labadie, Kevin P., Conticchio, Maria, Dogeas, Epameinondas, Giuffrida, Mario, Sommacale, Daniele, Laurent, Alexis, Magistri, Paolo, Nghia, Phan Phuoc, Mishima, Kohei, Krenzien, Felix, Schmelzle, Moritz, Kadam, Prashant, Liu, Qu, Lai, Eric C.H., Zheng, Junhao, Siow, Tiing Foong, Lim, Chetana, Mazzotta, Alessandro, Cauchy, Francois, Karam, Elias, Barbara, Marco, Pagano, Duilio, Ratti, Francesca
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2024
• Subjects: Aged; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Chemotherapy, Adjuvant; Coarsened exact-matched; Colorectal liver metastases; Colorectal Neoplasms - pathology; Difficulty score; Female; Hepatectomy - methods; Humans; Inverse probability treatment weighting; Liver Neoplasms - drug therapy; Liver Neoplasms - secondary; Liver Neoplasms - surgery; Male; Middle Aged; Minimally invasive liver surgery; Minimally Invasive Surgical Procedures - methods; Minor hepatectomy; Neoadjuvant chemotherapy; Neoadjuvant Therapy; Propensity Score; Propensity-score matched; Retrospective Studies; Treatment Outcome; Neoadjuvant chemotherapy; Minimally invasive liver surgery; Minor hepatectomy; Propensity-score matched; Colorectal liver metastases; Difficulty score; Inverse probability treatment weighting; Coarsened exact-matched
• ISSN: 0748-7983; 1532-2157; 1532-2157
• DOI: 10.1016/j.ejso.2024.108309

In the last three decades, minimally invasive liver resection has been replacing conventional open approach in liver surgery. More recently, developments in neoadjuvant chemotherapy have led to increased multidisciplinary management of colorectal liver metastases with both medical and surgical treatment modalities. However, the impact of neoadjuvant chemotherapy on the surgical outcomes of minimally invasive liver resections remains poorly understood. A multicenter, international, database of 4998 minimally invasive minor hepatectomy for colorectal liver metastases was used to compare surgical outcomes in patients who received neoadjuvant chemotherapy with surgery alone. To correct for baseline imbalance, propensity score matching, coarsened exact matching and inverse probability treatment weighting were performed. 2546 patients met the inclusion criteria. After propensity score matching there were 759 patients in both groups and 383 patients in both groups after coarsened exact matching. Baseline characteristics were equal after both matching strategies. Neoadjuvant chemotherapy was not associated with statistically significant worse surgical outcomes of minimally invasive minor hepatectomy. Neoadjuvant chemotherapy had no statistically significant impact on short-term surgical outcomes after simple and complex minimally invasive minor hepatectomy for colorectal liver metastases.