Synthesis and glycosidase inhibitory activity of pseudo-di-(or tri-)saccharides

The synthesis of pseudo-di-(or tri-)saccharides with a d-mannoazepane or a l-gulopiperidine skeleton either N-linked to a d- gluco- C-furanoside or to d-mannitol, and evaluation of their inhibitory activities against α- or β- d-glucosidase, α- d-mannosidase and α- l-fucosidase are described. Graphic...

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Bibliographic Details
Published inTetrahedron Vol. 59; no. 15; pp. 2693 - 2700
Main Authors McCort, Isabelle, Sanière, Michèle, Le Merrer, Yves
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 07.04.2003
Subjects
azepane
C-furanoside
glycosidases
mannitol
piperidine
pseudo-saccharides
piperidine
glycosidases
azepane
C-furanoside
mannitol
pseudo-saccharides
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Summary:The synthesis of pseudo-di-(or tri-)saccharides with a d-mannoazepane or a l-gulopiperidine skeleton either N-linked to a d- gluco- C-furanoside or to d-mannitol, and evaluation of their inhibitory activities against α- or β- d-glucosidase, α- d-mannosidase and α- l-fucosidase are described. Graphic
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(03)00257-6