Fibroblast Activation Protein Inhibitor Imaging and Therapy in a Patient With Multiple Endocrine Neoplasia Type 2A Syndrome

A patient with multiple endocrine neoplasia type 2A syndrome who had exhausted several surgeries and radiotherapy was referred to nuclear medicine department for theranostic approaches. [68Ga]-DOTATATE PET/CT and [131I]I-mIBG SPECT/CT were performed, but the degree of uptake was insufficient for usi...

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Bibliographic Details
Published inClinical nuclear medicine Vol. 47; no. 3; p. e284
Main Authors Barashki, Somaye, Divband, Ghasemali, Askari, Emran, Amini, Hamidreza, Aryana, Kamran
Format Journal Article
LanguageEnglish
Published United States 01.03.2022
Subjects
Fibroblasts
Humans
Iodine Radioisotopes
Multiple Endocrine Neoplasia Type 2a
Positron Emission Tomography Computed Tomography
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Summary:A patient with multiple endocrine neoplasia type 2A syndrome who had exhausted several surgeries and radiotherapy was referred to nuclear medicine department for theranostic approaches. [68Ga]-DOTATATE PET/CT and [131I]I-mIBG SPECT/CT were performed, but the degree of uptake was insufficient for using the treatment companion of these tracers. Finally, 1 year later, [68Ga]-FAPI-46 PET/CT showed progressive disease with metastases to the lung, liver, bone, and lymph nodes with intense [68Ga]-FAPI-46 uptake. Treatment with [177Lu]Lu-FAPI-46 was done, and the patient tolerated treatment and showed evidence of clinical improvement following therapy.
ISSN:1536-0229
DOI:10.1097/RLU.0000000000004051