A mild procedure for the clay catalyzed selective removal of the tert-butoxycarbonyl protecting group from aromatic amines

The application of solid acidic catalysts for the selective removal of N-Boc protection is presented in this report. Montmorillonite K10 was found to be an effective catalyst in removing aromatic N-Boc groups while leaving aliphatic N-Boc amines untouched.

Saved in:
Bibliographic Details
Published inTetrahedron letters Vol. 41; no. 3; pp. 385 - 387
Main Authors Shaikh, Nadim S, Gajare, Anil S, Deshpande, Vishnu H, Bedekar, Ashutosh V
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 15.01.2000
Elsevier
Subjects
Chemistry
Chemistry, Organic
clay catalysts
deprotection
N- tert-butoxycarbonyl amines
Physical Sciences
Science & Technology
deprotection
clay catalysts
N- tert-butoxycarbonyl amines
N-tert-butoxycarbonyl amines
NATURAL KAOLINITIC CLAY
Online AccessGet full text

Cover

More Information
Summary:The application of solid acidic catalysts for the selective removal of N-Boc protection is presented in this report. Montmorillonite K10 was found to be an effective catalyst in removing aromatic N-Boc groups while leaving aliphatic N-Boc amines untouched.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(99)02028-6