Evidence for the intermediacy of N-(2-imino, 1-oxo-propyl)-glycine in the base-catalyzed decomposition of N-halo-dipeptides

N-(2-imino, 1-oxo-propyl)-glycine are readily formed as intermediates in the base-catalyzed decomposition of (N-X)-Ala-Gly. These compounds suffer a subsequent hydrolysis to the corresponding N-(1,2-dioxo-propyl)-glycine. N-(2-imino-1-oxoalkyl)-amino acids are readily formed as intermediates in the...

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Published inTetrahedron Vol. 53; no. 37; pp. 12615 - 12620
Main Authors Armesto, X.L., Canle, M.L., García, M.V., Santaballa, J.A.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.09.1997
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Summary:N-(2-imino, 1-oxo-propyl)-glycine are readily formed as intermediates in the base-catalyzed decomposition of (N-X)-Ala-Gly. These compounds suffer a subsequent hydrolysis to the corresponding N-(1,2-dioxo-propyl)-glycine. N-(2-imino-1-oxoalkyl)-amino acids are readily formed as intermediates in the base-catalyzed decomposition of (N-X)-dipeptides. These compounds suffer a subsequent hydrolysis to the corresponding N-(1,2-dioxo)-amino acids.
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(97)00782-5