Structural characterisation and nuclease activity of mixed copper(II) complexes with sulfonamides and bipyridil
Mixed copper complexes have been synthetised through reaction of Cu(II) salts with bipyridil and N-quinolin-8-yl- p-toluenesulfonamide (Hqtsa), N-quinolin-8-yl-benzenesulfonamide (Hqbsa) or N-quinolin-8-yl-naftalenesulfonamide (Hqnsa). Single crystal X-ray diffraction structure determination shows t...
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Published in | Inorganica Chimica Acta Vol. 353; pp. 139 - 144 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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Elsevier B.V
08.09.2003
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Abstract | Mixed copper complexes have been synthetised through reaction of Cu(II) salts with bipyridil and
N-quinolin-8-yl-
p-toluenesulfonamide (Hqtsa),
N-quinolin-8-yl-benzenesulfonamide (Hqbsa) or
N-quinolin-8-yl-naftalenesulfonamide (Hqnsa). Single crystal X-ray diffraction structure determination shows that copper cations are five-coordinated, one complex have distorted bipyramidal trigonal geometry and the other have a distorted square-pyramid. The FT IR and EPR spectra are also reported. Electrophoresis results show that the synthetised complexes in the presence of ascorbate and hydrogen peroxide are chemical nucleases.
Mixed copper complexes with bipyridil and sulfonamides have been synthetised. Single crystal X-ray diffraction structure determination shows that copper cations are five-coordinated in a distorted square-pyramid geometry, with a chloride ligand in the axial position. The FT IR and EPR spectra are also reported. Electrophoresis results show that the complexes in the presence of ascorbate and hydrogen peroxide undergo extensive DNA cleavage. |
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AbstractList | Mixed copper complexes have been synthetised through reaction of Cu(II) salts with bipyridil and
N-quinolin-8-yl-
p-toluenesulfonamide (Hqtsa),
N-quinolin-8-yl-benzenesulfonamide (Hqbsa) or
N-quinolin-8-yl-naftalenesulfonamide (Hqnsa). Single crystal X-ray diffraction structure determination shows that copper cations are five-coordinated, one complex have distorted bipyramidal trigonal geometry and the other have a distorted square-pyramid. The FT IR and EPR spectra are also reported. Electrophoresis results show that the synthetised complexes in the presence of ascorbate and hydrogen peroxide are chemical nucleases.
Mixed copper complexes with bipyridil and sulfonamides have been synthetised. Single crystal X-ray diffraction structure determination shows that copper cations are five-coordinated in a distorted square-pyramid geometry, with a chloride ligand in the axial position. The FT IR and EPR spectra are also reported. Electrophoresis results show that the complexes in the presence of ascorbate and hydrogen peroxide undergo extensive DNA cleavage. |
Author | Villa, Marı́a V Castiñeiras, Alfonso González-Álvarez, Marta Macı́as, Benigno Borrás, Joaquı́n Garcı́a, Isabel |
Author_xml | – sequence: 1 givenname: Benigno surname: Macı́as fullname: Macı́as, Benigno email: bmacias@usal.es organization: Departamento de Quı́mica Inorgánica, Facultad de Farmacia, Campus Unamuno, Universidad de Salamanca, Avda. Campo Charro, s.n., E-37007 Salamanca, Spain – sequence: 2 givenname: Isabel surname: Garcı́a fullname: Garcı́a, Isabel organization: Departamento de Quı́mica Inorgánica, Facultad de Farmacia, Campus Unamuno, Universidad de Salamanca, Avda. Campo Charro, s.n., E-37007 Salamanca, Spain – sequence: 3 givenname: Marı́a V surname: Villa fullname: Villa, Marı́a V organization: Departamento de Quı́mica Inorgánica, Facultad de Farmacia, Campus Unamuno, Universidad de Salamanca, Avda. Campo Charro, s.n., E-37007 Salamanca, Spain – sequence: 4 givenname: Joaquı́n surname: Borrás fullname: Borrás, Joaquı́n organization: Departamento de Quı́mica Inorgánica, Facultad de Farmacia, Universidad de Valencia, Valencia, Spain – sequence: 5 givenname: Marta surname: González-Álvarez fullname: González-Álvarez, Marta organization: Departamento de Quı́mica Inorgánica, Facultad de Farmacia, Universidad de Valencia, Valencia, Spain – sequence: 6 givenname: Alfonso surname: Castiñeiras fullname: Castiñeiras, Alfonso organization: Departamento de Quı́mica Inorgánica, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela, Spain |
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Cites_doi | 10.1021/bk-1989-0402 10.1107/S0108767390000277 10.1016/0076-6879(91)08022-A 10.1016/S0162-0134(01)00302-6 10.1107/S0567739468000707 10.1016/S0020-1693(02)01167-2 10.1039/DT9840001349 10.1016/S0020-1693(00)85383-9 10.1016/S0162-0134(01)00369-5 10.1016/S0076-6879(97)77018-6 10.1016/0020-1693(96)04883-9 10.1002/9780470166390.ch7 10.1021/ic971154r 10.1021/cr00022a011 10.1016/S0020-1693(00)91973-X 10.1021/ja00402a060 |
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Keywords | Nuclease activity Bipyridil Copper(II) complexes Sulfonamides |
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Snippet | Mixed copper complexes have been synthetised through reaction of Cu(II) salts with bipyridil and
N-quinolin-8-yl-
p-toluenesulfonamide (Hqtsa),... |
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SubjectTerms | Bipyridil Copper(II) complexes Nuclease activity Sulfonamides |
Title | Structural characterisation and nuclease activity of mixed copper(II) complexes with sulfonamides and bipyridil |
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