Structural characterisation and nuclease activity of mixed copper(II) complexes with sulfonamides and bipyridil

• Published in: Inorganica Chimica Acta Vol. 353; pp. 139 - 144
• Main Authors: Macı́as, Benigno, Garcı́a, Isabel, Villa, Marı́a V, Borrás, Joaquı́n, González-Álvarez, Marta, Castiñeiras, Alfonso
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 08.09.2003
• Subjects: Bipyridil; Copper(II) complexes; Nuclease activity; Sulfonamides; Nuclease activity; Bipyridil; Copper(II) complexes; Sulfonamides
• ISSN: 0020-1693; 1873-3255
• DOI: 10.1016/S0020-1693(03)00236-6

Mixed copper complexes have been synthetised through reaction of Cu(II) salts with bipyridil and N-quinolin-8-yl- p-toluenesulfonamide (Hqtsa), N-quinolin-8-yl-benzenesulfonamide (Hqbsa) or N-quinolin-8-yl-naftalenesulfonamide (Hqnsa). Single crystal X-ray diffraction structure determination shows that copper cations are five-coordinated, one complex have distorted bipyramidal trigonal geometry and the other have a distorted square-pyramid. The FT IR and EPR spectra are also reported. Electrophoresis results show that the synthetised complexes in the presence of ascorbate and hydrogen peroxide are chemical nucleases. Mixed copper complexes with bipyridil and sulfonamides have been synthetised. Single crystal X-ray diffraction structure determination shows that copper cations are five-coordinated in a distorted square-pyramid geometry, with a chloride ligand in the axial position. The FT IR and EPR spectra are also reported. Electrophoresis results show that the complexes in the presence of ascorbate and hydrogen peroxide undergo extensive DNA cleavage.