A new method for deprotection of benzothiazolesulfonamides using a thiol and base

Benzothiazolesulfonamides of primary and secondary amines are efficiently cleaved by a nucleophilic aromatic substitution with a thiol and a base such as potassium t-butoxide or diisopropylethyl amine in DMF. Graphic

Saved in:
Bibliographic Details
Published inTetrahedron letters Vol. 39; no. 50; pp. 9155 - 9156
Main Authors Wuts, Peter G.M., Gu, Rui Lin, Jill, Northuis M., Thomas, Collette L.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 10.12.1998
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
PROTECTION
Online AccessGet full text

Cover

More Information
Summary:Benzothiazolesulfonamides of primary and secondary amines are efficiently cleaved by a nucleophilic aromatic substitution with a thiol and a base such as potassium t-butoxide or diisopropylethyl amine in DMF. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(98)02107-8