Palytoxin: an inexhaustible source of inspiration—personal perspective

• Published in: Tetrahedron Vol. 58; no. 32; pp. 6239 - 6258
• Main Author: Kishi, Yoshito
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 05.08.2002
• Subjects: acyclic compounds; palytoxin; stereochemistry; stereocontrol; palytoxin; stereochemistry; stereocontrol; acyclic compounds
• ISSN: 0040-4020; 1464-5416
• DOI: 10.1016/S0040-4020(02)00624-5

A personal perspective is given on the research programs which have originated from, or are related to, the marine natural product palytoxin. The subjects discussed include: acyclic stereocontrol, Ni(II)/Cr(II)-mediated coupling reaction, stereochemical assignment via organic synthesis, universal NMR database, chiral NMR solvents, conformational analysis of C- and O-glycosides, diamond-lattice analysis, Type II O blood group determinant C- and O-trisaccharides, sMMP/ sMGP, and CH 2-bridged Watson-Crick base-pair models. A personal perspective is given on the research programs which have originated from, or are related to, the marine natural product palytoxin. The subjects discussed include: acyclic stereocontrol, Ni(II)/Cr(II)-mediated coupling reaction, stereochemical assignment via organic synthesis, universal NMR database, chiral NMR solvents, conformational analysis of C- and O-glycosides, diamond-lattice analysis, Type II O blood group determinant C- and O-trisaccharides, sMMP/ sMGP, and CH 2-bridged Watson-Crick base-pair models.