A regioselective synthesis of 8,9-dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine (LY134046), a potent phenylethanolamine N-methyltransferase inhibitor

A regioselective synthesis of 2,3,4,5-tetrahydro-1 H-2-benzazepines substituted on the aryl and/or azepine rings is presented and used for the preparation of the title compound in overall yield of 22% from intermediate 1. Graphic

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 1; no. 1; pp. 59 - 60
Main Authors Grunewald, Gary L., Paradkar, Vidyadhar M.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 1991
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Summary:A regioselective synthesis of 2,3,4,5-tetrahydro-1 H-2-benzazepines substituted on the aryl and/or azepine rings is presented and used for the preparation of the title compound in overall yield of 22% from intermediate 1. Graphic
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(01)81091-X