Reductive defluorination of polyfluoroarenes by zinc in aqueous ammonia

Aqueous ammonia has been found to be a good and versatile medium for the reductive defluorination of polyfluoroarenes by zinc. Upon the reduction of pentafluorobenzoic acid, 2,3,4,5,6-pentafluorobenzyl alcohol, pentafluoropyridine and heptafluoro-2-naphthoic acid individual products derived from the...

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Bibliographic Details
Published inTetrahedron letters Vol. 38; no. 21; pp. 3765 - 3768
Main Authors Laev, Sergey S., Shteingarts, Vitalij D.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 26.05.1997
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Summary:Aqueous ammonia has been found to be a good and versatile medium for the reductive defluorination of polyfluoroarenes by zinc. Upon the reduction of pentafluorobenzoic acid, 2,3,4,5,6-pentafluorobenzyl alcohol, pentafluoropyridine and heptafluoro-2-naphthoic acid individual products derived from the removal of one fluorine atom have been obtained. Aqueous ammonia has been found to be a good and versatile medium for the reductive defluorination of polyfluoroarenes by zinc. Upon the reduction of some polyfluoroarenes individual products from the removal of one fluorine have been obtained.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(97)00730-2