Conjugate addition of nitrogen nucleophiles to an α, β-unsaturated pyrrolidinone

The conjugate addition of nitrogen nucleophiles to α,β-unsaturated lactam 1b under very mild conditions occurs in good yield with high diastereoselectivity. Deprotection provides a simple access to β-aminopyrrolidinones in excellent overall yield. Graphic

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Bibliographic Details
Published inTetrahedron letters Vol. 38; no. 33; pp. 5891 - 5894
Main Authors Chan, Philip W.H, Cottrell, Ian F, Moloney, Mark G
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 18.08.1997
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
BETA-AMINO ACIDS
CHIRAL BICYCLIC LACTAMS
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Summary:The conjugate addition of nitrogen nucleophiles to α,β-unsaturated lactam 1b under very mild conditions occurs in good yield with high diastereoselectivity. Deprotection provides a simple access to β-aminopyrrolidinones in excellent overall yield. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(97)01312-9