A New Antitumor Isoquinoline Alkaloid from the Marine Nudibranch Jorunna funebris

A new dimeric isoquinoline alkaloid, jorumycin ( 3), has been isolated from the skin and the mucus of the Pacific nudibranch Jorunna funebris. The structure has been fully elucidated on the grounds of ESMS data and of an extensive 2D NMR analysis. The cytotoxicity of 3 was evaluated against various...

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Bibliographic Details
Published inTetrahedron Vol. 56; no. 37; pp. 7305 - 7308
Main Authors Fontana, Angelo, Cavaliere, Paolo, Wahidulla, Solimabi, Naik, Chandrakant G., Cimino, Guido
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 08.09.2000
Elsevier
Subjects
alkaloid
antitumor
Chemistry
Chemistry, Organic
molluscs
Physical Sciences
Science & Technology
molluscs
alkaloid
antitumor
ECTEINASCIDIN-743
CARIBBEAN TUNICATE
SPONGE RENIERA SP
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Summary:A new dimeric isoquinoline alkaloid, jorumycin ( 3), has been isolated from the skin and the mucus of the Pacific nudibranch Jorunna funebris. The structure has been fully elucidated on the grounds of ESMS data and of an extensive 2D NMR analysis. The cytotoxicity of 3 was evaluated against various human cancer cell lines and was found to be slightly less potent than Et 743 ( 2).
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(00)00629-3