Comparison of Amniotic Fluid Cytokine Levels in Postterm and Term Pregnancy: a Prospective Study

• Published in: Clinical laboratory (Heidelberg) Vol. 63; no. 2; p. 235
• Main Authors: Korkmaz, Vakkas, Cekmez, Yasemin, Surer, Hatice, Deveci, Canan D, Ocal, Fatma D, Gezer, Murad, Kurdoglu, Zehra, Ergun, Yusuf, Kucukozkan, Tuncay
• Format: Journal Article
• Language: English
• Published: Germany 01.01.2017
• Subjects: Adult; Amniotic Fluid - immunology; Case-Control Studies; Cytokines - analysis; Female; Gestational Age; Humans; Infant, Postmature; Interleukin-10 - analysis; Interleukin-4 - analysis; Interleukin-6 - analysis; Pregnancy; Pregnancy, Prolonged - immunology; Prospective Studies; Term Birth - immunology; Young Adult
• ISSN: 1433-6510
• DOI: 10.7754/Clin.Lab.2016.160711

To evaluate amniotic fluid pro- and anti-inflammatory cytokine levels in women with postterm and term pregnancies in labor and not in labor. The study involved three groups: postterm (Group 1, n = 29), term in labor (Group 2, n = 28), and control (Group 3, n = 30). All groups were compared with respect to age, gravidity, parity, obstetric history, gestation week, cervical dilatation and effacement, maternal serum C-reactive protein and white cell count, amniotic interleukin 4, 6, and 10 levels, birthweight, and cord blood pH. The amniotic fluid interleukin 10 level was 24.4 ± 8.8 pg/mL in the postterm group, 13.5 ± 5.1 pg/mL in the term in labor group, and 19.8 ± 5.4 pg/mL in the control group (p < 0.001). The amniotic fluid interleukin 4 level was 86.5 ± 57.7 pg/mL in the postterm group, 38.2 ± 29.2 pg/mL in the term in labor group, and 81.9 ± 68.4 pg/mL in the control group (p = 0.002). The amniotic fluid interleukin 6 level was 329 ± 135.1 pg/mL in the postterm group, 252.8 ± 138.7 pg/mL in the term in labor group, and 227.9 ± 114.4 pg/mL in the control group (p = 0.02). There was a positive correlation between gestational age and IL-10 levels (p < 0.05). Amniotic fluid IL-10 and IL-4 cytokine levels were increased in postterm pregnancy and they decreased with active labor.