A novel three-step hydroxy-deamination sequence: Conversion of lysine to 6-hydroxynorleucine derivatives
Oxidation of carbamates with catalytic RuO 4, generated from RuO 2 and NaBrO 3, provides the corresponding acyl carbamates, which can be reduced with NaBH 4 to provide alcohols. Application of this methodology to L-lysine provides ( S)-6-hydroxynorleucine derivatives. Graphic
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Published in | Tetrahedron letters Vol. 39; no. 32; pp. 5671 - 5674 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier Ltd
06.08.1998
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Oxidation of carbamates with catalytic RuO
4, generated from RuO
2 and NaBrO
3, provides the corresponding acyl carbamates, which can be reduced with NaBH
4 to provide alcohols. Application of this methodology to L-lysine provides (
S)-6-hydroxynorleucine derivatives.
Graphic |
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ISSN: | 0040-4039 1873-3581 |
DOI: | 10.1016/S0040-4039(98)01142-3 |