Improvement of menopausal symptoms by oat hull extracts in ovariectomized animal model

Female menopause is a disease characterized by the gradual loss of ovarian function that occurs before and after menopause. Female menopausal symptoms include osteoporosis, facial flushing, and dyslipidemia. Oats are known to be rich in protein and lipids, and their hulls are mainly used as feed. In...

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Published inBiotechnology and bioprocess engineering Vol. 30; no. 3; pp. 464 - 474
Main Authors Lee, Mi-Ja, Lee, Yongjin, Lee, Han Gyeol, Jin, Holim, Shin, Yoon-A., Song, Seung Yeob, Seo, Woo Duck, Son, Young-Jin
Format Journal Article
LanguageEnglish
Published Seoul The Korean Society for Biotechnology and Bioengineering 01.06.2025
Springer Nature B.V
한국생물공학회
Subjects
Animal models
Biomarkers
Biotechnology
Body weight
Bone density
Bone mineral density
Breast cancer
Chemistry
Chemistry and Materials Science
Dietary fiber
Dyslipidemia
Estrogens
Females
Fermentation
Food science
Gene expression
Hulls
In vivo methods and tests
Industrial and Production Engineering
Lipids
Menopause
Metabolic disorders
Oats
Osteoporosis
Ovariectomy
Ovaries
Protein expression
Proteins
Reproductive status
Research Paper
Signs and symptoms
Womens health
생물공학
Bone mineral density
Menopausal symptoms
Oat hull
Ovariectomized
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Summary:Female menopause is a disease characterized by the gradual loss of ovarian function that occurs before and after menopause. Female menopausal symptoms include osteoporosis, facial flushing, and dyslipidemia. Oats are known to be rich in protein and lipids, and their hulls are mainly used as feed. In this study, we sought to explore the potential of oat hull extract as a treatment for menopause by analyzing its estrogen-like activity and menopause-related biomarkers in ovariectomized (OVX) animals. We investigated changes in mRNA expression and estrogen activity of several menopause-related genes induced by oat hull extract in vitro using MCF-7 breast cancer cells. Additionally, we used an OVX mouse model to investigate the effects of oat hull extract on menopause in vivo through changes in body weight, tissue morphology, and bone mineral density. Therefore, this study suggests that oat hull extract may be a promising alternative for treating female menopause.
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ISSN:1226-8372
1976-3816
DOI:10.1007/s12257-025-00189-8