Modeling surfactant-induced hemolysis by Weibull survival analysis

It is demonstrated that surfactant-induced, slow hemolysis (usually attributed to an osmotic mechanism) is very well described by the two-parameter Weibull distribution. The Weibull shape parameter depends on blood properties. The Weibull scale parameter is found to be determined by the amount of me...

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Bibliographic Details
Published inColloids and surfaces, B, Biointerfaces Vol. 27; no. 2; pp. 223 - 229
Main Authors Shalel, Sagit, Streichman, Sara, Marmur, Abraham
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.02.2003
Subjects
Erythrocyte
Hemolysis
Surfactant
Survival analysis
Weibull distribution
Erythrocyte
Hemolysis
Survival analysis
Surfactant
Weibull distribution
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Summary:It is demonstrated that surfactant-induced, slow hemolysis (usually attributed to an osmotic mechanism) is very well described by the two-parameter Weibull distribution. The Weibull shape parameter depends on blood properties. The Weibull scale parameter is found to be determined by the amount of membrane-bound surfactant per cell, which is controlled by the suspending solution composition. For hemolysis that involves also a rapid stage (usually attributed to solubilization), the Weibull distribution fits the experimental data if the hemolysis fraction and time are measured relative to the end point of the rapid stage.
ISSN:0927-7765
1873-4367
DOI:10.1016/S0927-7765(02)00075-9