Total synthesis of rhizoxin D

The convergent, enantiocontrolled synthesis of a significant antimitotic agent for cancer chemotherapy is presented with completion of rhizoxin diene 2.

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Bibliographic Details
Published inTetrahedron letters Vol. 38; no. 39; pp. 6825 - 6828
Main Authors Williams, David R., Werner, Kim M., Feng, Bainian
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 29.09.1997
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
1ST TOTAL SYNTHESIS
CARBON-ATOMS
MAYTANSINE
ANTITUMOR MACROLIDE
MACROCYCLIC LACTONE ANTIBIOTICS
RHIZOPUS-CHINENSIS
PHOMOPSIN-A
TUBULIN
SELECTIVITY
BINDING
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Summary:The convergent, enantiocontrolled synthesis of a significant antimitotic agent for cancer chemotherapy is presented with completion of rhizoxin diene 2.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(97)01605-5