Multiple tubulovillous adenomas of the vulva

Enteric-type lesions are rare in the female genital tract. We report the first case of multiple vulvar tubulovillous adenomas with transformation into adenocarcinoma. A 31-year-old woman presented with recurrent vulvar polypoid lesions resembling condylomas that were excised. These tumors were chara...

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Bibliographic Details
Published inThe American journal of dermatopathology Vol. 34; no. 3; p. 321
Main Authors Karkouche, Raymond, Ansart, Frédéric, Terris, Benoit, Lavenu, Marie CécileVacher, Plantier, Françoise
Format Journal Article
LanguageEnglish
Published United States 01.05.2012
Subjects
Adenocarcinoma - diagnosis
Adenocarcinoma - metabolism
Adenocarcinoma - surgery
Adenoma, Villous - diagnosis
Adenoma, Villous - metabolism
Adenoma, Villous - surgery
Adult
Biomarkers, Tumor - metabolism
Cell Transformation, Neoplastic
Condylomata Acuminata - pathology
Disease Progression
Disease-Free Survival
Female
Humans
Neoplasm Recurrence, Local
Neoplasms, Multiple Primary
Treatment Outcome
Vulvar Neoplasms - diagnosis
Vulvar Neoplasms - metabolism
Vulvar Neoplasms - surgery
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Summary:Enteric-type lesions are rare in the female genital tract. We report the first case of multiple vulvar tubulovillous adenomas with transformation into adenocarcinoma. A 31-year-old woman presented with recurrent vulvar polypoid lesions resembling condylomas that were excised. These tumors were characterized by their tubulovillous architecture and intestinal differentiation, with columnar epithelium, goblet cells, and Paneth cells. As in their colonic counterpart, the degree of dysplasia was evaluated. The lesions consisted of 3 low-grade adenomas and 1 adenocarcinoma with superficial invasion. After 15 months, there is no sign of recurrence. The clinical presentation, pathological findings, differential diagnoses, and pathogenesis are discussed.
ISSN:1533-0311
DOI:10.1097/DAD.0b013e3182288e29