Retrospective analysis of aspirin and ticlopidine in preventing recurrent stroke following an initial lacunar infarct

• Published in: Journal of stroke and cerebrovascular diseases Vol. 5; no. 1; pp. 44 - 48
• Main Author: Weisberg, Leon A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 1995
• Subjects: Antiplatelet medication; Aspirin; Lacunar infarction; Recurrent stroke; Ticlopidine; Transient ischemic attack; Lacunar infarction; Antiplatelet medication; Recurrent stroke; Aspirin; Transient ischemic attack; Ticlopidine
• ISSN: 1052-3057; 1532-8511
• DOI: 10.1016/S1052-3057(10)80086-2

Of 73 patients with initial lacunar stroke subsequently treated with aspirin, 13 (18%) developed recurrent stroke (11 lacunar infarcts and 2 nonlacunar infarcts), and 4 (5%) died within 1 year. Of the aspirin-treated lacunar infarct patients, 58 received 325 mg or lower-dose aspirin, and 15 received 600–1,300 mg of aspirin. Thirteen aspirin-treated patients who developed recurrent ischemic stroke received 80 mg or 325 mg of aspirin, whereas recurrent stroke did not occur in 15 patients treated with 600–1,300 mg of aspirin daily. Of 25 patients with lacunar stroke who were subsequently treated with 250 mg of ticlopidine twice daily, 1 patient (4%) developed recurrent lacunar infarct, and none died within 1 year. Of 10 patients who had an initial lacunar stroke and subsequently received no antiplatelet medication, 4 (40%) developed recurrent lacunar stroke, and 1 (10%) died within 1 year.