A Case of Intranasal Ketamine Misuse: Considerations for Clinical Practice

Despite the growing off-label use of ketamine for depression and other psychiatric indications, its long-term safety profile and abuse potential remain unclear. We present a case of a patient who presented with paranoia and personality changes attributed to ketamine misuse, which illustrates the nee...

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Bibliographic Details
Published inJournal of psychiatric practice Vol. 27; no. 6; p. 492
Main Authors Rivas-Grajales, Ana M, Mathew, Sanjay J, Rodgers, Joshua J
Format Journal Article
LanguageEnglish
Published United States 05.11.2021
Subjects
Humans
Ketamine - adverse effects
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Summary:Despite the growing off-label use of ketamine for depression and other psychiatric indications, its long-term safety profile and abuse potential remain unclear. We present a case of a patient who presented with paranoia and personality changes attributed to ketamine misuse, which illustrates the need for more robust screening and systematic monitoring with this medication. Continued evaluation of the abuse potential of ketamine in long-term treatment as well as restricted access and in-office administration are important, to develop a better understanding of the risk-benefit profile of this drug.
ISSN:1538-1145
DOI:10.1097/PRA.0000000000000589