The synthesis of potentially selective inhibitors of dihydroorotate dehydrogenase. The utilization of chemoselective Suzuki cross-coupling reactions in a parallel synthesis

A series of potentially selective inhibitors of dihydroorotate dehydrogenase (DHODH) were synthesized via iterative, chemoselective Suzuki cross-couplings utilizing biaryl chlorides as key intermediates. A series of potentially selective inhibitors of dihydroorotate dehydrogenase (DHODH) were synthe...

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Bibliographic Details
Published inTetrahedron letters Vol. 42; no. 4; pp. 547 - 551
Main Authors Sutton, Amanda E, Clardy, Jon
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 22.01.2001
Elsevier
Subjects
biaryl chloride
Chemistry
Chemistry, Organic
dihydroorotate dehydrogenase
Physical Sciences
Science & Technology
Suzuki cross-coupling
dihydroorotate dehydrogenase
biaryl chloride
Suzuki cross-coupling
ORGANOBORON COMPOUNDS
ARYL CHLORIDES
ARYLBORONIC ACIDS
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Summary:A series of potentially selective inhibitors of dihydroorotate dehydrogenase (DHODH) were synthesized via iterative, chemoselective Suzuki cross-couplings utilizing biaryl chlorides as key intermediates. A series of potentially selective inhibitors of dihydroorotate dehydrogenase (DHODH) were synthesized via iterative, chemoselective Suzuki cross-couplings utilizing biaryl chlorides as key intermediates.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(00)02024-4