Synthesis and Antiproliferative Activities of 1‐Hydroxyindole‐2‐Carboxylates

Synthesis and evaluation of antiproliferative activities of 1‐hydroxyindole‐2‐carboxylates 1 were described. The toluene compounds 3 were treated with dimethyl oxalate and then, dimethylmethyleneammonium chloride to give intermediates 2. Compounds 2 were converted to desired compounds 1 by applicati...

Full description

Saved in:
Bibliographic Details
Published inBulletin of the Korean Chemical Society Vol. 39; no. 4; pp. 512 - 515
Main Authors Park, Yeon Kyeong, Ryu, Yea Seong, Cho, Hyunsung, Chung, Ha Sook, Lee, Sang Hyup
Format Journal Article
LanguageEnglish
Published Weinheim Wiley‐VCH Verlag GmbH & Co. KGaA 01.04.2018
대한화학회
Subjects
A2058 cells
Antiproliferative activity
Conjugate nitrone
HCT116
Hydroxyindole
MDA‐Mb‐231
Stannous chloride
화학
Online AccessGet full text

Cover

More Information
Summary:Synthesis and evaluation of antiproliferative activities of 1‐hydroxyindole‐2‐carboxylates 1 were described. The toluene compounds 3 were treated with dimethyl oxalate and then, dimethylmethyleneammonium chloride to give intermediates 2. Compounds 2 were converted to desired compounds 1 by application of the reaction of 1‐hydroxyindole formation using SnCl2·2H2O and thiol (or alcohol). The measurements of antiproliferative activities of compounds 1a, 1b, and 1c against several cell lines revealed that compounds 1a and 1c showed strong antiproliferative activities in HCT116 and A2058 cancer cells and could serve as promising lead compounds for further development of anticancer agents.
Bibliography:https://onlinelibrary.wiley.com/doi/full/10.1002/bkcs.11418
ISSN:1229-5949
0253-2964
1229-5949
DOI:10.1002/bkcs.11418