Primary B-cell non-Hodgkin lymphoma of the parotid gland: An analysis based on the SEER database

• Published in: Medicine (Baltimore) Vol. 102; no. 17; p. e33098
• Main Authors: Chen, Xiang-Lei, Zhao, Lu-Ming, Cai, Yuan-Hua, Li, Jing-Gang, Li, Xin
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 25.04.2023
• Subjects: Humans; Lymphoma - epidemiology; Lymphoma, B-Cell - epidemiology; Observational Study; Parotid Gland; Parotid Neoplasms - epidemiology; Prognosis; SEER Program
• ISSN: 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000033098

Primary malignant lymphoma of the parotid gland is a rare entity. The disease is often misdiagnosed, and its survival factors remain unclear. This study included patients diagnosed with primary B-cell non-Hodgkin lymphoma of the parotid gland from 1987 to 2016 in the surveillance, epidemiology, and end results program. Univariate survival analysis was conducted using the Kaplan-Meier method, and multivariate analysis was performed using the Cox proportional hazards regression model. A competing risks regression model was applied to estimate the specific risks associated with parotid lymphoma mortality. A total of 1443 patients were identified. The overall survival of indolent primary B-cell lymphoma of the parotid gland was higher than that of aggressive lymphoma (hazard ratio 0.53, 95% confidence interval 0.44-0.64, P < .001), and older patients (≥70 years) exhibited inferior overall survival. Histological subtype and age are important prognostic factors in patients with primary B-cell non-Hodgkin lymphoma of the parotid gland.