A case report of Sho-saiko-to induced hepatic and renal injury

• Published in: Kanzo Vol. 36; no. 12; pp. 712 - 718
• Main Authors: SAKAI, Takahisa, KUNIYOSHI, Mikio, NAKAMURA, Masatsugu, NAKANO, Takeshi, TAMEDA, Yukihiko, KOSAKA, Yoshitane
• Format: Journal Article
• Language: English; Japanese
• Published: The Japan Society of Hepatology 1995
• ISSN: 0451-4203; 1881-3593
• DOI: 10.2957/kanzo.36.712

We report a case of hepato-renal injury induced by Sho-saiko-to used in Japan for treatment of chronic hepatitis. A 60-year-old man with a history of acute hepatic injury and renal injury during administration of Sho-saiko-to for chronic hepatitis C, was admitted to our hospital because of acute hepato-renal injury. He took Sho-saiko-to again before admission, and suspected to have Sho-saiko-to induced hepatic injury. He was recovered but was readmitted because of fever and general fatigue on the following day due to accidental taking of Sho-saiko-to. Laboratory data on readmission revealed as follows; AST 314IU/l. ALT 308IU/l, serum bilirubin 2.8mg/dl, BUN 26.7mg/d/, Cr 1.8mg/dl. He was recovered as soon as he stopped taking Sho-saiko-to. Lymphocyte stimulation test for each 4 components of Sho-saiko-to involving "Ninjin", "Hange", "Ougon", and "Taiso", was positive. It is necessary to take into consideration to hepatic and renal injury on the occasion of treatment with Sho-saiko-to.