Experimental versus numerical data for breast cancer progression

This paper deals with a mouse model of breast cancer based on two mammary adenocarcinoma cell lines derived from a spontaneous tumor of the mammary gland in a female BALB/c mouse. We investigate both animal and mathematical models of tumor progression, and demonstrate a correspondence between the ex...

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Bibliographic Details
Published inNonlinear analysis: real world applications Vol. 13; no. 1; pp. 78 - 84
Main Authors Jorcyk, C.L., Kolev, M., Tawara, K., Zubik-Kowal, Barbara
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.02.2012
Subjects
Animal model
Cell lines
Integro-differential equations
Mammary
Numerical simulations
Tumor progression
Animal model
Integro-differential equations
Numerical simulations
Mammary
Cell lines
Tumor progression
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Summary:This paper deals with a mouse model of breast cancer based on two mammary adenocarcinoma cell lines derived from a spontaneous tumor of the mammary gland in a female BALB/c mouse. We investigate both animal and mathematical models of tumor progression, and demonstrate a correspondence between the experimental and predicted data. The mathematical model is solved numerically and the laboratory data are utilized in order to find unknown parameters for the model equations. The results of the numerical experiments illustrate that the mathematical model has a potential to describe the growth of cancer cells in vivo.
ISSN:1468-1218
1878-5719
DOI:10.1016/j.nonrwa.2011.07.014