Facile synthesis of α-tertiary alkyl/aryl amines via cu-catalyzed alkylation of indoles and anilines with tertiary alkyl bromides

[Display omitted] Methods of copper-catalyzed alkylation of indoles and anilines with tertiary alkyl bromides were reported. These protocols provided various N-tert-alkyl 3-substituted indoles and electron-deficient N-tert-alkyl anilines in moderate to good yields via CN coupling.

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Bibliographic Details
Published inTetrahedron letters Vol. 129; pp. 154730 - 154733
Main Authors Duan, Gaoyu, Qian, Qun, Chen, Yunrong
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 06.10.2023
Elsevier
Subjects
Alkyl radicals
Alkylation
Chemistry
Chemistry, Organic
Cu-catalyzed
C–N coupling
Physical Sciences
Science & Technology
α-Tertiary amines
Alkyl radicals
C–N coupling
α-Tertiary amines
Alkylation
Cu-catalyzed
SUBSTITUTION
AMINATION
alpha-Tertiary amines
Cu -catalyzed
C-N coupling
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Summary:[Display omitted] Methods of copper-catalyzed alkylation of indoles and anilines with tertiary alkyl bromides were reported. These protocols provided various N-tert-alkyl 3-substituted indoles and electron-deficient N-tert-alkyl anilines in moderate to good yields via CN coupling.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2023.154730